| 货号 | 9000552-5mg |
| 描述 | Oleoyl ethanolamide-d4 contains four deuterium atoms at the hydroxyethyl 1,1,2, and 2 positions. It is intended for use as an internal standard for the quantification of oleoyl ethanolamide by GC- or LC-mass spectrometry. Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate.1 It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,2 but its biosynthesis is reduced in the intestine of rats following food deprivation.3 OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay.4 Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.3,4 These data indicate that OEA regulates food intake by a PPARα-mediated mechanism. |
| 别名 | OEA-d4;Oleic Acid Ethanolamide-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.di Tomaso, E.,Beltramo, M., and Piomelli, D. Brain cannabinoids in chocolate. Nature 382, 677-678 (1996). 2.Epps, D.E.,Palmer, J.W.,Schmid, H.H.O., et al. Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acelethanolamines, a class of lipids synthesized in ischemic heart tissue. The Journal of Biological Chemisty 257, 1383-1392 (1982). 3.de Fonseca, F.R.,Navarro, M.,Gómez, R., et al. An anorexic lipid mediator regulated by feeding. Nature 414, 209-212 (2001). 4.Fu, J.,Gaetani, S.,Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425, 90-93 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 329.6 |
| 分子式 | C20H35D4NO2 |
| CAS号 | 946524-36-3 |
| 稳定性 | ≥ 1 year |
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