PHOP
货号：
71655-5mg 基本售价：
13720.0 元 规格：
5 mg
产品信息
概述| 货号 | 71655-5mg |
| 描述 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PHOP is a potent FAAH inhibitor, exhibiting Ki values of 0.094 nM and 0.2 nM for the human and rat enzymes, respectively.1 Using a proteomics approach, PHOP was screened against the serine hydrolase family of enzymes, of which FAAH is a member. In this assay, PHOP exhibited IC50 values of 1.1 nM, 1.4 nM, and >100 µM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively.2 Knowledge of the specificity of PHOP obtained from this experiment should allow for more accurate interpretation of results using this inhibitor in complex environments such as whole cells or animals. |
| 别名 | CAY10402;Phenyl hexanoyl oxazolopyridine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Boger, D.L.,Sato, H.,Lerner, A.E., et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide. Proceedings of the National Academy of Sciences of the United States of America 97, 5044-5049 (2000).
2.Leung, D.,Hardouin, C.,Boger, D.L., et al. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nature Biotechnology 21(6), 687-691 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 294.4 |
| 分子式 | C18H18N2O2 |
| CAS号 | 288862-83-9 |
| 稳定性 | ≥ 1 year |
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