CAY10410
货号：
18590-10mg 基本售价：
13720.0 元 规格：
10 mg
产品信息
概述| 货号 | 18590-10mg |
| 描述 | CAY10410 is an analog of prostaglandin D2/prostaglandin J2(PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ.1 Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Δ12-PGJ2occursvia glutathione addition across the α,β unsaturated enone.2 CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.3 |
| 别名 | 9,10-dihydro-15-deoxy-Δ12,14-PGJ2;9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Forman, B.M.,Tontonoz, P.,Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995).
2.Atsmon, J.,Sweetman, B.J.,Baertschi, S.W., et al. Formation of thiol conjugates of 9-deoxy-Δ9,Δ12(E)-prostaglandin D2 and Δ12(E)-prostaglandin D2. Biochemistry 29, 3760-3765 (1990).
3.Shibata, T.,Yamada, T.,Ishii, T., et al. Thioredoxin as a molecular target of cyclopentenone prostaglandins. The Journal of Biological Chemisty 278(28), 26046-26054 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% (isomer mixture) |
| 计算分子量 | 318.5 |
| 分子式 | C20H30O3 |
| CAS号 | 596104-94-8 |
| 稳定性 | ≥ 1 year |
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