TAK-960
货号：
17701-50mg 基本售价：
13720.0 元 规格：
50 mg
产品信息
概述| 货号 | 17701-50mg |
| 描述 | Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.1,2 It exhibits greater than 20-fold selectivity for Plk1 over FAK, MLCK, and the tyrosine protein kinase Fes, and has minimal activity against a panel of 282 other kinases.1,2 It inhibits the proliferation of various cancer cell lines, including MDR1-expressing tumors, and also prevents tumor growth in several human cancer cell xenograft models, including a disseminated model of AML- and MDR1-expressing hematological tumors.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hikichi, Y.,Honda, K.,Hikami, K., et al. TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. Molecular Cancer Therapeutics 11(3), 700-709 (2012).
2.Nie, Z.,Feher, V.,Natala, S., et al. Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Bioorganic & Medicinal Chemistry Letters 23(12), 3662-3666 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 561.6 |
| 分子式 | C27H34F3N7O3 |
| CAS号 | 1137868-52-0 |
| 稳定性 | ≥ 2 years |
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