PtdIns-(3,4,5)-P3 (1-stearoyl, 2-docosahexaenoyl) (sodium salt)
货号：
9000829-1mg 基本售价：
13706.0 元 规格：
1 mg
产品信息
概述| 货号 | 9000829-1mg |
| 描述 | Phosphatidyl inositol trisphosphate (PtdIns-(3,4,5)-P3) is a membrane phospholipid that may be cleaved by phospholipase C (PLC) to produce the second messengers inositol tetrakisphosphate (IP4) and diacylglycerol (DAG). IP4 triggers an increase in intracellular calcium.1PtdIns-(3,4,5)-P3 (1-stearoyl, 2-docosahexaenoyl) is an uncommon phospholipid having the ω-3 fatty acid docosahexaenoate (DHA) in the sn-2 position. In addition to releasing an unusual DHA-containing DAG in response to PLC, this phospholipid can serve as a source of DHA in response to phospholipases A2(PLA2). Importantly, the inositol head group of PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of proteins bearing pleckstrin homology (PH) domains.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lückhoff, A., and Clapham, D.E. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel. Nature 355, 356-358 (1992).
2.Ferguson, K.M.,Kavran, J.M.,Sankaran, V.G., et al. Structural basis for discrimination of 3-phosphoinisitides by pleckstrin homology domains. Molecular Cell 6(2), 373-384 (2000).
3.Lemmon, M.A., and Ferguson, K.M. Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides. Biochemical Society Transactions 29(4), 377-384 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1239 |
| 分子式 | C49H82O22P4 • 4Na |
| 稳定性 | ≥ 1 year |
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