Bischloroanthrabenzoxocinone
货号：
19439-2.5mg 基本售价：
13678.0 元 规格：
2.5 mg
产品信息
概述| 货号 | 19439-2.5mg |
| 描述 | Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics.1 Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty acid synthesis in S. aureusandE. coli with IC50 values of 11.4 and 35.3 µg/ml, respectively.2 It inhibits the growth of S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2-0.4 µg/ml.2,3 BABX also displays binding to liver X receptors (LXRs), inhibiting agonist binding in an LXRα-scintillation proximity assay (IC50 = 10 µM).3 |
| 别名 | BABX;(―)-Bischloroanthrabenzoxocinone; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yao, J., and Rock, C.O. How bacterial pathogens eat host lipids: Implications for the development of fatty acid synthesis therapeutics. The Journal of Biological Chemisty 290(10), 5940-5946 (2015).
2.Kodali, S.,Galgoci, A.,Young, K., et al. Determination of selectivity and efficacy of fatty acid synthesis inhibitors. The Journal of Biological Chemisty 280(2), 1669-1677 (2005).
3.Herath, K.B.,Jayasuriya, H.,Guan, Z., et al. Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents. Journal of Natural Products 68(9), 1437-1440 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 543.4 |
| 分子式 | C28H24Cl2O7 |
| CAS号 | 866022-28-8 |
| 稳定性 | ≥ 2 years |
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