| 货号 | 15502-1mg |
| 描述 | Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM).1 In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport.1,2,3 Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes.2,3 It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface.4,5 |
| 别名 | 8-deethyl-8-methyl-Concanamycin A;MCH 210; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yilla, M.,Tan, A.,Ito, K., et al. Involvement of the vacuolar H+-ATPases in the secretory pathway of HepG2 cells. The Journal of Biological Chemisty 268(25), 19092-19100 (1993). 2.Woo, J.T.,Ohba, Y.,Tagami, K., et al. Concanamycin B, a vacuolar H+-ATPase specific inhibitor suppresses bone resorption in vitro. Biological and Pharmaceutical Bullentin 19(2), 297-299 (1996). 3.Lee, M.H.,Kataoka, T.,Honjo, N., et al. In vivo rapid reduction of alloantigen-activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B. Immunology 99(2), 243-248 (2000). 4.Bénaroch, P.,Yilla, M.,Raposo, G., et al. How MHC class II molecules reach the endocytic pathway. EMBO Journal 14(1), 37-49 (1995). 5.Ito, K.,Kobayashi, T.,Moriyama, Y., et al. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. J.Antibiot.(Tokyo) 48(6), 488-494 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 851.5 |
| 分子式 | C45H73NO14 |
| CAS号 | 81552-33-2 |
| 稳定性 | ≥ 2 years |
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