| 货号 | 15504-2.5mg |
| 描述 | Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces.1 It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90.1,2,3 Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf.2,4 Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites.5,6,7,8 Ansamycins, including herbimycin A and geldanamycin (Item No. 13355), bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.3,9 |
| 别名 | Antibiotic TAN 420F;NSC 305978; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Omura, S.,Iwai, Y.,Takahashi, Y., et al. Herbimycin, a new antibiotic produced by a strain of Streptomyces. J.Antibiot.(Tokyo) 32(4), 255-261 (1979). 2.Uehara, Y. and Fukazawa, H. Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases. Methods in Enzymology 201, 371-379 (1991). 3.Blagosklonny, M.V. Hsp-90-associated oncoproteins: Multiple targets of geldanamycin and its analogs. Leukemia 16(4), 455-462 (2002). 4.Fukazawa, H.,Li, P.M.,Yamamoto, C., et al. Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro. Biochemical Pharmacology 42(9), 1661-1671 (1991). 5.Fan, T.P.D.,Jaggar, R. and Bicknell, R. Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends in Pharamacological Sciences 16(2), 57-66 (1995). 6.Ogina, S.,Tsuruma, K.,Uehara, T., et al. Herbimycin A abrogates nuclear factor-κB activation by interacting preferentially with the IκB kinase β subunit. Molecular Pharmacology 65(6), 1344-1351 (2004). 7.Park, D.J.,Min, H.K. and Rhee, S.G. IgE-induced tyrosine phosphorylation of phospholipase C-γ1 in rat basophilic leukemia cells. The Journal of Biological Chemisty 266(36), 24237-24240 (1991). 8.Buro, C.,Oliveira, K.C.,Lu, Z., et al. Transcriptome analyses of inhibitor-treated schistosome females provide evidence for cooperating Src-kinase and TGFβ receptor pathways controlling mitosis and eggshell formation. PLoS Pathogens 9(6), e1003448 (2013). 9.Whitesell, L.,Mimnaugh, E.G.,De Costa, B., et al. Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proceedings of the National Academy of Sciences of the United States of America 91, 8324-8328 (1994). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 574.7 |
| 分子式 | C30H42N2O9 |
| CAS号 | 70563-58-5 |
| 稳定性 | ≥ 2 years |
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