| 货号 | 21586-25mg |
| 描述 | 15(R)-Prostaglandin I2(15(R)-PGI2) is an isomer of the natural 15(S) prostanoid, PGI2 (Item No. 18220). PGI2 is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells.1,2,3 It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 value of 5 nM.4 While the physiological properties of 15(R)-PGI2 are not well known, 15(R) isomers of PGs typically have reduced receptor agonist activity compared to their 15(S) forms. |
| 别名 | 15(R)-PGI2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moncada, S.,Gryglewski, R.,Bunting, S., et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263, 663-665 (1976). 2.Johnson, R.A.,Morton, D.R.,Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins 12, 915-928 (1976). 3.Stehle, R.G. Physical chemistry, stability, and handling of prostaglandins E2, F2α, D2 and I2: A critical summary. Methods Enzymol. 86, 436-459 (1982). 4.Aristoff, P.A.,Johnson, P.D. and Harrison, A.W. Synthesis of 9-substituted carbacyclin analogues. J. Org. Chem. 48, 5341-5348 (1983). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.5 |
| 分子式 | C20H31O5 • Na |
| 稳定性 | ≥ 2 years |
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