ALK-IN-1
货号：
18775-50mg 基本售价：
13482.0 元 规格：
50 mg
产品信息
概述| 货号 | 18775-50mg |
| 描述 | ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).1 It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, W.S.,Liu, S.,Zou, D., et al. Discovery of brigatinib (AP26113), a phosphine oxide-containing, potent, orally active inhibitor of anaplastic lymphoma kinase. Journal of Medicinal Chemistry (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 529 |
| 分子式 | C26H34ClN6O2P |
| CAS号 | 1197958-12-5 |
| 稳定性 | ≥ 2 years |
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