| 货号 | 17918-25mg |
| 描述 | N1,N12-Acetylspermine is a diacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.1 Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.2,3 Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.4 |
| 别名 | BAS; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bolkenius, F.N. and Seiler, N. Acetylderivatives as intermediates in polyamine catabolism. International Journal of Biochemistry 13(3), 287-292 (1981). 2.Wallace, H.M.,Fraser, A.V. and Hughes, A. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003). 3.Igarashi, K. and Kashiwagi, K. Polyamines: Mysterious modulators of cellular functions. Biochemical and Biophysical Research Communications 271(3), 559-564 (2000). 4.Johnson, C.H.,Dejea, C.M.,Edler, D., et al. Metabolism links bacterial biofilms and colon carcinogenesis. Cell Metabolism 21(6), 891-897 (2015). | |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 359.3 |
| 分子式 | C14H30N4O2 • 2HCl |
| CAS号 | 77928-71-3 |
| 稳定性 | ≥ 2 years |
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