| 货号 | 1202/50 |
| 别名 | 4-[5-(4-Fluorophenyl)-2-[4-(methyls |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. Essential component of medium for maintaining stem cells in naive pluripotent state. Part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Water-soluble salt SB 203580 hydrochloride (Cat. No. 1402) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 377.44 |
| 分子式 | C21H16FN3OS |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 100 mM in 1eq. HCl |
| CAS号 | 152121-47-6 |
| 参考文献 | Gafniet al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282. PMID: 24172903. Satoet al (2008) Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. J.Neurosci.Res. 86 2179. PMID: 18338804. Davieset al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351. Borsch-Hauboldet al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 273 28766. PMID: 9786874. Saklatvalaet al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 271 6586. PMID: 8636072. |