| 货号 | 4995/50 |
| 别名 | (2S)-2,6-Diamino-N-[4-(5-fluoro-2-b |
| 供应商 | Tocris |
| 生物活性 | Prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 459.41 |
| 分子式 | C20H23FN4OS.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Bradshaw and Westwell (2004) The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate. Curr.Med.Chem. 11 1241. PMID: 15078163. Leonget al (2004) In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Mol.Cancer Ther. 3 1565. PMID: 15634650. Leonget al (2003) Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitroandin vivo. Br.J.Cancer 88 470. PMID: 12569393. Trapaniet al (2003) DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells. Br.J.Cancer 88 599. PMID: 12592376. |