| 货号 | 4986/50 |
| 别名 | 3-[(6-Amino-5-(3,4,5-trimethoxyphen |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro(IC50 = 100 nM) and induces dorsalization of zebrafish embryos. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 352.38 |
| 分子式 | C20H20N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming |
| 参考文献 | Mohedaset al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291. PMID: 23547776. Sanvitaleet al (2013) A new class of small molecule inhibitor of BMP signaling. PLoS ONE 8 62721. PMID: 23646137. |