AZ 12080282 dihydrochloride (50 MG)
货号：
4838/50 基本售价：
13463.9 元 规格：
50 mg
产品信息
概述| 货号 | 4838/50 |
| 别名 | N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Inhibitor of Hedgehog (Hh) signaling (IC50<0.012μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 457.35 |
| 分子式 | C23H20N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Yanget al (2012) Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg.Med.Chem.Lett. 22 4907. PMID: 22704236. |
