| 货号 | 9000537-250mg |
| 描述 | Amiodarone (Item No. 15213) is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.1 It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.2 In humans, cytochrome P450 3A is involved in the metabolism of amiodarone.3 N-Desethylamiodarone is the major, active metabolite of amiodarone. This compound has been used as an analytical reference standard for quantifying amiodarone in plasma samples.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Campbell, T.J., and Williams, K.M. Therapeutic drug monitoring: Antiarrhythmic drugs. British Journal of Clinical Pharmacology 46, 307-319 (1998). 2.Sinha, N., and Sen, S. Predicting hERG activities of compounds from their 3D structures: Development and evaluation of a global descriptors based QSAR model. European Journal of Medicinal Chemistry 46(2), 618-630 (2011). 3.Shayeganpour, A.,El-Kadi, A.O.S., and Brocks, D.R. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: The contribution of cytochrome P450 3A isoforms. Drug Metabolism and Disposition 34(1), 43-50 (2006). 4.Pérez-Ruiz, T.,Martínez-Lozano, C., and García-Martínez, M.D. Simultaneous determination of amiodarone and its metabolite desethylamiodarone by high-performance liquid chromatography with chemiluminescent detection. Analytica Chimica Acta 623(1), 89-95 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 653.73 |
| 分子式 | C23H25I2NO3 • HCl |
| CAS号 | 96027-74-6 |
| 稳定性 | ≥ 2 years |
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