Galiellalactone
货号：
15387-5mg 基本售价：
13426.0 元 规格：
5 mg
产品信息
概述| 货号 | 15387-5mg |
| 描述 | Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM.1 The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor.1 At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Weidler, M.,Rether, J.,Anke, T., et al. Inhibition of interleukin-6 signaling by galiellalactone. FEBS Letters 484(1), 1-6 (2000).
2.Hellsten, R.,Johansson, M.,Dahlman, A., et al. Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells. PLoS One 6(7), e221188 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 194.2 |
| 分子式 | C11H14O3 |
| CAS号 | 133613-71-5 |
| 稳定性 | ≥ 2 years |
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