UK 1
货号：
20139-5mg 基本售价：
13384.0 元 规格：
5 mg
产品信息
概述| 货号 | 20139-5mg |
| 描述 | UK 1 is a metabolite from Streptomyces sp. 517-02 that demonstrates cytotoxic activity against various cancer cell lines, though it does not have antibacterial effects.1 It has been shown to inhibit topoisomerase II and also to inhibit hepatitis C viral replication.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ueki, M.,Ueno, K.,Miyadoh, S., et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J.Antibiot.(Tokyo) 46(7), 1089-1094 (1993).
2.Reynolds, M.B.,DeLuca, M.R. and Kerwin, S.M. The novel Bis(benzoxazole) Cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II. Bioorg.Chem. 27(4), 326-337 (1999).
3.Ward, D.N.,Talley, D.C.,Tavag, M., et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg.Med.Chem.Lett. 24(2), 609-612 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 386.4 |
| 分子式 | C22H14N2O5 |
| CAS号 | 151271-53-3 |
| 稳定性 | ≥ 2 years |
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