Kazusamycin A
货号：
20137-500ug 基本售价：
13384.0 元 规格：
500 ug
产品信息
概述| 货号 | 20137-500ug |
| 描述 | Kazusamycin A is an antibiotic from Streptomyces and a hydroxy analog of Leptomycin B (Item No. 10004976) that demonstrates cytotoxic activity against various human and mouse tumor lines.1 Additionally, at nanomolar concentrations, it inhibits nuclear export and translocation of Rev, a regulatory gene product in the HIV genome.2,3 |
| 别名 | CL 1,957B;Hydroxyelactocin;Hydroxyleptomycin B;PD 114721; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tunac, J.B.,Graham, B.D.,Dobson, W.E., et al. Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity. J.Antibiot.(Tokyo) 38(4), 460-465 (1985).
2.Wang, Y.,Ponelle, M.,Sanglier, J.-J., et al. Novel leptomycins from a Streptomyces strain A92-308902: Inhibitors of the nucleo-cytoplasmic translocation of the HIV-1 regulatory protein rev. Helv. Chim. Acta. 80(7), 2157-2167 (1997).
3.Wolff, B.,Sanglier, J.-J. and Wang, Y. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem.Biol. 4(2), 139-147 (1997).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 556.7 |
| 分子式 | C33H48O7 |
| CAS号 | 92090-94-3 |
| 稳定性 | ≥ 2 years |
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