Dihydroeponemycin
货号：
10007805-5mg 基本售价：
13384.0 元 规格：
5 mg
产品信息
概述| 货号 | 10007805-5mg |
| 描述 | Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X.1,2 It potently inhibits both the chymotrypsin-like and PGPH activity, with 10-fold less inhibition of trypsin-like activity.2 Dihydroeponemycin does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations.2 It is cell-permeable and induces apoptosis in bovine aortic endothelial cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ho, Y.K.,Bargagna-Mohan, P.,Wehenkel, M., et al. LMP2-specific inhibitors: chemical genetic tools for proteasome biology. Chem. Biol. 14(4), 419-430 (2007).
2.Meng, L.,Kwok, B.H.B.,Sin, N., et al. Eponemycin exerts its antitumor effect through the inhibition of proteasome function. Cancer Research 59, 2798-2801 (1999).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 2-8 |
| 纯度 | ≥98% |
| 计算分子量 | 400.5 |
| 分子式 | C20H36N2O6 |
| CAS号 | 126463-64-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
