| 货号 | 15381-5mg |
| 描述 | Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions.1,2 Ophiobolin A is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, blocking the activation of calmodulin-dependent phosphodiesterase with an IC50 value of 9 μM.3 It antagonizes a variety of forms of calmodulin from plants and animals by binding covalently to conserved lysine residues.4,5 |
| 别名 | Cochliobolin;NSC 114340; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chin, D. and Means, A.R. Calmodulin: A prototypical calcium sensor. Trends in Cell Biology 10(8), 322-328 (2000). 2.Berchtold, M.W. and Villalobo, A. The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer. Biochimica et Biophysica Acta 1843(2), 398-435 (2014). 3.Leung, P.C.,Taylor, W.A.,Wang, J.H., et al. Ophiobolin A. A natural product inhibitor of calmodulin. The Journal of Biological Chemisty 259(5), 2742-2747 (1984). 4.Au, T.K. and Leung, P.C. Identification of the binding and inhibition sites in the calmodulin molecule for ophiobolin A by site-directed mutagenesis. Plant Physiology 118(3), 965-973 (1998). 5.Leung, P.C.,Taylor, W.A.,Wang, J.H., et al. Role of calmodulin inhibition in the mode of action of ophiobolin A. Plant Physiology 77(2), 303-308 (1985). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 400.6 |
| 分子式 | C25H36O4 |
| CAS号 | 990299 |
| 稳定性 | ≥ 2 years |
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