NH125
货号：
10011250-50mg 基本售价：
13230.0 元 规格：
50 mg
产品信息
概述| 货号 | 10011250-50mg |
| 描述 | NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria 1. In bacteria, NH125 inhibits several histidine kinases, inhibiting YycG with an IC50 of 6.6 µM 2. NH125 also decreases the viability of several cancer cell lines with IC50 values ranging from 0.7-4.7 µM 3. In mammalian cells, NH125 strongly inhibits eEF-2K (IC50 = 60 nM), with weaker effects on protein kinase C (IC50=7.5 µM), protein kinase A (IC50=80 µM), and calmodulin-dependent kinase II (IC50=100 µM)3. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yamamoto, K.,Kitayama, T.,Ishida, N., et al. Identification and characterization of a potent antibacterial agent, NH125 against drug-resistant bacteria. Bioscience, Biotechnology, and Biochemistry 64(4), 919-923 (2000).
2.Yamamoto, K.,Kitayama, T.,Minagawa, S., et al. Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis. Bioscience, Biotechnology, and Biochemistry 65(10), 2306-2310 (2001).
3.Arora, S.,Yang, J.M.,Kinzy, T.G., et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Research 63, 6894-6899 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 524.6 |
| 分子式 | C27H45IN2 |
| CAS号 | 278603-08-0 |
| 稳定性 | ≥ 2 years |
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