| 货号 | 18441-5mg |
| 描述 | 8-bromo-cGMP (Item No. 15992) is a cell-permeable analog of cGMP that exhibits resistance to hydrolysis by phosphodiesterases. It preferentially activates cGMP-dependent protein kinase (cGK).1 Rp-8-bromo-Cyclic GMPS (Rp-8-bromo-cGMPS) is a cell-permeable cGMP analog that adds an equatorial exocyclic (Rp) sulfur substitution in the axial position of the cyclophosphate ring of 8-bromo-cGMP. Like 8-bromo-cGMP, Rp-8-bromo-cGMPS is resistant to hydrolysis by phosphodiesterases. This Rp isomer binds cGK without activating it, resulting in competitive inhibition.2,3 At 10 µM, it blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1 (Item No. 82220).4 |
| 别名 | Rp-8-bromo-cGMPS; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rashatwar, S.S.,Cornwell, T.L., and Lincoln, T.M. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: Possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 84(16), 5685-5689 (1987). 2.Butt, E.,van Bemmelen, M.,Fischer, L., et al. Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3,5-monophosphorothioates. FEBS Letters 263(1), 47-50 (1990). 3.Butt, E.,Pöhler, D.,Genieser, H.G., et al. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS. British Journal of Pharmacology 116, 3110-3116 (1995). 4.Ouedraogo, S.,Tschöp, M.,Stoclet, J.C., et al. Effects of cyclic GMP and analogues on neurogenic transmission in the rat tail artery. British Journal of Pharmacology 112, 867-872 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 462.1 |
| 分子式 | C10H10BrN5O6PS • Na |
| CAS号 | 208445-06-1 |
| 稳定性 | ≥ 2 years |
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