| 货号 | 1580/50 |
| 别名 | (2R)-2-[[6-[(3-Chlorophenyl)amino]- |
| 供应商 | Tocris |
| 生物活性 | Cyclin-dependent kinase inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 388.9 |
| 分子式 | C19H25ClN6O |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 212844-53-6 |
| 参考文献 | Bainet al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199. PMID: 12534346. Villerbuet al (2002) Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int.J.Cancer 97 761. PMID: 11857351. Grayet al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859. PMID: 10495356. Grayet al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533. PMID: 9677190. |