| 货号 | 0900/50 |
| 别名 | 2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt |
| 供应商 | Tocris |
| 生物活性 | A competitive antagonist at P2Y1 receptors (KB = 100 nM). Selective over P2X1(IC50 = 1.15 μM), P2X3(IC50 = 12.9 μM), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors. Inhibits the upregulation of NTPDase1 by ATPγS. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 513.16 |
| 分子式 | C11H13N5O9P2Na4 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 101204-49-3 |
| 参考文献 | Luet al (2007) Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. J.Pharmacol.Exp.Ther. 323 157. PMID: 17626796. Brownet al (2000) Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev.Res. 49253. Nandananet al (2000) Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands. J.Med.Chem. 43 829. PMID: 10715151. Boyeret al (1998) Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate. Br.J.Pharmacol. 124 1. PMID: 9630335. |