| 货号 | 4471/50 |
| 别名 | 6-[4-[2-(4-Morpholinyl)ethoxy]pheny |
| 供应商 | Tocris |
| 生物活性 | Selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Displays antiangiogenic activity in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 400.47 |
| 分子式 | C24H24N4O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Haoet al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245. PMID: 20020776. Fraleyet al (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg.Med.Chem.Lett. 12 3537. PMID: 12443771. |