| 货号 | 4534/50 |
| 别名 | N-[2-[[5-Chloro-2-[[2-methoxy-4-(4- |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 541.45 |
| 分子式 | C22H25ClN6O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Krameret al (2012) Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem.Neurosci. 3 151. PMID: 22860184. Ramsdenet al (2011) Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinsons disease-related toxicity in human neurons. ACS Chem.Biol. 6 1021. PMID: 21812418. |