| 货号 | 13196-25mg |
| 描述 | Rac1 is a GTPase that is involved in the regulation of the cell cycle, cell-cell adhesion, motility, and differentiation.1 Rac1 is activated by its interaction with specific guanine nucleotide exchange factors (GEFs). NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 μM).2 It has no effect on the closely related GTPases, Cdc42 and RhoA. NSC23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, and gene expression.3,4,5,6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bosco, E.E.,Mulloy, J.C. and Zheng, Y. Rac1 GTPase: A "Rac" of all trades. Cellular and Molecular Life Sciences 66, 370-374 (2009). 2.Gao, Y.,Dickerson, J.B.,Guo, F., et al. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proceedings of the National Academy of Sciences of the United States of America 101(20), 7618-7623 (2004). 3.Cancelas, J.A.,Lee, A.W.,Prabhakar, R., et al. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nature Medicine 11(8), 886-891 (2005). 4.Rao, J.N.,Liu, S.V.,Zou, T., et al. Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-γ1 after wounding. American Journal of Physiology.Cell Physiology 295, C1499-C1509 (2008). 5.Sawada, N.,Salomone, S.,Kim, H.H., et al. Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1. Circulation Research 103, 360-368 (2008). 6.Wang, J.,Rao, Q.,Wang, M., et al. Overexpression of Rac1 in leukemia patients and its role in leukemia cell migration and growth. Biochemical and Biophysical Research Communications 386, 769-774 (2009). 7.Vallon, M.,Rohde, F.,Janssen, K.P., et al. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation. Experimental Cell Research 316, 412-421 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 531 |
| 分子式 | C24H35N7 • 3HCl |
| CAS号 | 1177865-17-6 |
| 稳定性 | ≥ 2 years |
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