| 货号 | 10627-25mg |
| 描述 | 4-hydroxy Nonenal Glutathione (HNE-GSH) is a major adduct formed by the reaction of 4-HNE with GSH.1,2,3,4 4-HNE-GSH levels in liver, plasma, or isolated cells can serve as biomarkers for oxidative stress.5 The trapping of 4-HNE by glutathione to give HNE-GSH prevents the formation of DNA adducts with 4-HNE.6,7 In human polymorphonuclear leukocytes, HNE-GSH is metabolized to 1,4-dihydroxynonene glutathione (DHN-GSH), 4-hydroxynonenoic acid glutathione (HNA-GSH), and 4-hydroxy nonenal mercapturic acid (HNE-MA).1 |
| 别名 | 4-HNE-GSH; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Siems, W.,Crifo, C.,Capuozzo, E., et al. Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes. Archives of Biochemistry and Biophysics 503, 248-252 (2010). 2.Laurent, A.,Alary, J.,Debrauwer, L., et al. Analysis in the rat of 4-hydroxynonenal metabolites excreted in bile: Evidence of enterohepatic circulation of these byproducts of lipid peroxidation. Chemical Research in Toxicology 12, 887-894 (1999). 3.Siems, W., and Grune, T. Intracellular metabolism of 4-hydroxynonenal. Mol.Aspects Med. 24, 167-175 (2003). 4.Alary, J.,Fernandez, Y.,Debrauwer, L., et al. Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat. Chemical Research in Toxicology 16, 320-327 (2003). 5.Völkel, W.,Alvarez-Sánchez, R.,Weick, I., et al. Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats. Free Radical Biology & Medicine 38, 1526-1536 (2005). 6.King, A.O.,Corley, E.G.,Anderson, R.K., et al. An efficient synthesis of LTD4 antagonist L-699,392. The Journal of Organic Chemistry 58, 3731-3735 (1993). 7.Falletti, O.,Cadet, J.,Favier, A., et al. Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells. Free Radical Biology & Medicine 42, 1258-1269 (2007). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 577.6 |
| 分子式 | C19H33N3O8S • CF3COOH |
| 稳定性 | ≥ 1 year |
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