| 货号 | 516811-480Well |
| 描述 | Latanoprost is 13,14-dihydro-17-phenyl-18,19,20-trinor prostaglandin F2α isopropyl ester (13,14-dihydro-17-phenyl-18,19,20-trinor PGF2α isopropyl ester), an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1,2,3 Prostaglandin esters and other similar derivatives act as prodrugs which are converted to the active free acid form by an esterase/amidase activity in ocular tissues. The free acid form of Latanoprost (Latanoprost free acid (Lat-FA), or PhXA 85) is 200 times more potent than the isopropyl ester as an FP receptor ligand tested using the recombinant human FP receptor.2 Although the exact mechanism of the intraocular hypotensive effect of prostaglandins is unknown, it correlates very closely with the FP receptor ligand binding affinity of FP receptor agonists.4 The Cayman Latanoprost ELISA is a sensitive detection method for measuring the free acid form of Latanoprost. It also detects the isopropyl ester form of Latanoprost, but with less sensitivity. The assay is most appropriate for use when only one of the two forms is present. Samples containing mixtures of both the isopropyl ester and free acid should be purified and the two compounds separated prior to ELISA analysis. |
| 别名 | Latanoprost EIA Kit;17-phenyl-13,14-dihydro trinor Prostaglandin F2α;17-phenyl-13,14-dihydro trinor Prostaglandin F2α isopropyl ester;PhXA 85; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Stjernschantz, J. and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17, 691-704 (1992). 2.Abramovitz, M.,Adam, M.,Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000). 3.Camras, C.B.,Alm, A.,Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103, 1916-1924 (1996). 4.Cravatt, B.F.,Giang, D.K.,Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384, 83-87 (1996). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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