| 货号 | 16768-25mg |
| 描述 | Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity.1,2 Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.1,2 It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 µg/kg to terminate pregnancy.3 It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10−11M.4 |
| 别名 | 16-m-trifluoromethylphenoxy tetranor Prostaglandin F2α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abramovitz, M.,Boie, Y.,Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. The Journal of Biological Chemisty 269, 2632-2636 (1994). 2.Lake, S.,Gullberg, H.,Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Letters 355, 317-325 (1994). 3.Dukes, M.,Russell, W. and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α. Nature 250, 330-331 (1974). 4.Serrero, G. and Lepak, N.M. Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochemical and Biophysical Research Communications 233, 200-202 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 458.5 |
| 分子式 | C23H29F3O6 |
| CAS号 | 54276-17-4 |
| 稳定性 | ≥ 2 years |
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