| 货号 | 5493/50 |
| 别名 | 8-Chloro-2-(2S)-2-pyrrolidinylbenzo |
| 供应商 | Tocris |
| 生物活性 | Potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 326.18 |
| 分子式 | C14H12ClN3O2 |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| 参考文献 | Sasiet al (2014) The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 9 e113300. PMID: 25412417. Koltunet al (2012) Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 22 3727. PMID: 22560567. |