| 货号 | 3371/50 |
| 别名 | (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective OX2 receptor antagonist (IC50 = 40 nM). Displays >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2receptor. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 433.97 |
| 分子式 | C23H31N3O3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 25 mM in DMSO |
| CAS号 | 372523-75-6 |
| 参考文献 | Mouldet al (2014) Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br.J.Pharmacol. 171 351. PMID: 23692283. Hiroseet al(2003)N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist. Bioorg.Med.Chem.Lett. 13 4497. PMID: 14643355. |