| 货号 | 3222/50 |
| 别名 | N-(4-Amino-5-cyano-6-ethoxy-2-pyrid |
| 供应商 | Tocris |
| 生物活性 | ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 356.38 |
| 分子式 | C18H20N4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Kauskotet al (2007) Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J.Biol.Chem. 282 31990. PMID: 17785464. Szczepankiewiczet al (2006) Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 49 3563. PMID: 16759099. |