| 货号 | 2592/50 |
| 别名 | (4-Bromo-3,6-dimethoxybenzocyclobut |
| 供应商 | Tocris |
| 生物活性 | High affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. adminitration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 353.05 |
| 分子式 | C11H14BrNO2.HBr |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| 参考文献 | Niebertet al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395. PMID: 21789169. Foxet al (2010) The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology 212 13. PMID: 19823806. McLeanet al (2006) 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. J.Med.Chem. 49 5794. PMID: 16970404. |