TC Mps1 12 (50 MG)
货号：
4750/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 4750/50 |
| 别名 | 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 324.38 |
| 分子式 | C17H20N6O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming |
| 参考文献 | Kusakabeet al (2012) Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med.Chem.Lett. 3 560. PMID: 24900510. |
