| 货号 | 4254/50 |
| 别名 | N-[4-[2-Ethyl-4-(3-methylphenyl)-5- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 399.51 |
| 分子式 | C24H21N3OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Verkaaret al (2011) Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 18 485. PMID: 21513885. Miwatashiet al (2005) Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 48 5966. PMID: 16162000. |