| 货号 | 4484/50 |
| 别名 | 4-[[[[4-(1,1-Dimethylethyl)phenyl]s |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 423.53 |
| 分子式 | C23H25N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Kroppet al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl.Med. 4 483. PMID: 25834119. Adamset al (2014) NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem.Biol. 9 2247. PMID: 25058389. Chanet al (2011) Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 3 94ra70. PMID: 21813754. |