| 货号 | 2190/50 |
| 别名 | 2-[[[4-(2-Chlorophenyl)-2-thiazolyl |
| 供应商 | Tocris |
| 生物活性 | Potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 411.86 |
| 分子式 | C20H14ClN3O3S |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 136381-85-6 |
| 参考文献 | Canoet al (2003) Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 140 647. PMID: 14534148. Gouldsonet al (1999) Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 383 339. PMID: 10594328. Gullyet al (1993) Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol. 23232. |