| 货号 | 4964/50 |
| 别名 | 4-[(2-Fluorophenyl)sulfonyl]-3,4-di |
| 供应商 | Tocris |
| 生物活性 | Selective and high affinity 5-HT6 antagonist (pKi = 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 450.35 |
| 分子式 | C18H20FN3O3< |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Liuet al (2009) 5-HT6 antagonists as potential treatment for cognitive dysfunction. Drug Des.Rev. 70145. Zhaoet al (2007) 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists. Bioorg.Med.Chem.Lett. 17 3504. PMID: 17485206. |