| 货号 | 3731/50 |
| 别名 | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethy |
| 供应商 | Tocris |
| 生物活性 | Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 464.64 |
| 分子式 | C30H40O4 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 1258-84-0 |
| 参考文献 | Byunet al (2009) Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells. Mol.Pharmacol. 76 734. PMID: 19574249. Kinget al (2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem.Biol. 16 1045. PMID: 19875078. Tiedemannet al (2009) Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo. Blood 113 4027. PMID: 19096011. |