| 货号 | 4621/50 |
| 别名 | 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3 |
| 供应商 | Tocris |
| 生物活性 | Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 432 |
| 分子式 | C21H22ClN3OS |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 50 mM in DMSO |
| 参考文献 | Paturyet al (2009) Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 9 1337. PMID: 19860737. Wadhwaet al (2002) Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 62 4434. PMID: 12154051. Wadhwaet al (2000) Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60 6818. PMID: 11156371. Tikooet al (1999) Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 5 293. PMID: 10526670. |