| 货号 | 4949/50 |
| 别名 | (3S)-3-(5-Chloro-2-methoxyphenyl)-3 |
| 供应商 | Tocris |
| 生物活性 | Potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 359.7 |
| 分子式 | C16H10ClF4NO |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Jeppset al (2012) One mans side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders. Br.J.Pharmacol. 168 19. PMID: 22880633. Hamashimaet al (2005) Catalytic enantioselective fluorination of oxindoles. J.Am.Chem.Soc. 127 10164. PMID: 16028916. Korsgaardet al (2005) Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J.Pharmacol.Exp.Ther. 314 282. PMID: 15814569. |