| 货号 | 3079/50 |
| 别名 | 4-Fluoro-N-[3-(1-methyl-4-piperidin |
| 供应商 | Tocris |
| 生物活性 | Selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 387.88 |
| 分子式 | C21H22FN3O.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO with gentle warming |
| CAS号 | 182563-08-2 |
| 参考文献 | Wainscottet al (2005) [H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn-Schmied.Arch.Pharmacol. 371169. Shepheardet al (1999) Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370. Cephalalgia 19 851. PMID: 10668103. Dupuiset al (1998) G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines. Br.J.Pharmacol. 124 283. PMID: 9641544. |