| 货号 | 3342/50 |
| 别名 | N-[(5-Bromo-2-methoxyphenyl)sulfony |
| 供应商 | Tocris |
| 生物活性 | Potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 536.44 |
| 分子式 | C27H22BrNO4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 244101-02-8 |
| 参考文献 | Bassilet al (2008) Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br.J.Pharmacol. 154 126. PMID: 18332851. Clarkeet al (2004) E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype. Br.J.Pharmacol. 141 600. PMID: 14744812. Juteauet al (2001) Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP3 prostanoid receptor. Bioorg.Med.Chem. 9 1977. PMID: 11504634. |