| 货号 | 3086/50 |
| 别名 | 5-Amino-1-[[3,5-dichloro-4-(4-chlor |
| 供应商 | Tocris |
| 生物活性 | Orally active Ca2+ channel blocker; inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 424.67 |
| 分子式 | C17H12Cl3N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 99519-84-3 |
| 参考文献 | Yanget al (2008) Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. Int.J.Cancer. 123 258. PMID: 18464258. Felderet al (1991) The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J.Pharm.Exp.Ther. 257967. Hupeet al (1991) The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582 J.Biol.Chem. 266 10136. PMID: 1645340. |