| 货号 | 2660/50 |
| 别名 | 5-(2-Fluorophenyl)-1,3-dihydro-3-(1 |
| 供应商 | Tocris |
| 生物活性 | Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 397.44 |
| 分子式 | C25H20FN3O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 103342-82-1 |
| 参考文献 | Chadhaet al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377. PMID: 22251082. Jowet al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443. PMID: 16945016. Seebohmet al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941. PMID: 14576198. Salataet al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53220. |