| 货号 | 1382/50 |
| 别名 | 5,5-Dimethyl-2-(2,3,4,9-tetrahydro- |
| 供应商 | Tocris |
| 生物活性 | Potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). Displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 366.46 |
| 分子式 | C23H26O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 6508-43-6 |
| 参考文献 | Mashikoet al (2007) A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Mol.Pharmacol. 71 602. PMID: 17105869. Schroederet al (2005) The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats. Alcohol 36 179. PMID: 16377459. Kanataniet al (2000) L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem.Biophys.Res.Commun. 272 169. PMID: 10872822. |