Ki 8751 (50 MG)
货号：
2542/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 2542/50 |
| 别名 | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea |
性能| 供应商 | Tocris |
| 生物活性 | Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo; antiangiogenic. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 469.41 |
| 分子式 | C24H18F3N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 228559-41-9 |
| 参考文献 | Kuboet al (2005) Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumour activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas. J.Med.Chem. 48 1359. PMID: 15743179. |
