| 货号 | 2666/50 |
| 别名 | N-[4-(4-Methyl-1-piperazinyl)phenyl |
| 供应商 | Tocris |
| 生物活性 | α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C,α2B,α2Dandα2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro(KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 441.4 |
| 分子式 | C24H24N4.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 5 mM in DMSO |
| CAS号 | 80259-18-3 |
| 参考文献 | Sallinenet al (2007) Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302. Br.J.Pharmacol. 150 391. PMID: 17220913. Tricklebank (2007) JP-1302: a new tool to shed light on the roles of α2C-adrenoceptors in brain. Br.J.Pharmacol. 150 381. PMID: 17220912. |